LC-MS-Based Metabolic Fingerprinting of Aqueous Humor

Figure 2

Metabolic pathway analysis. Metabolic pathway analysis was performed with MetaboAnalyst 3.0. Calculated p value was established based on the pathway enrichment analysis while pathway impact value based on the pathway topology analysis. Twenty of the most significant pathways are marked with the numbers: 1. phenylalanine metabolism, 2. taurine and hypotaurine metabolism, 3. arginine and proline metabolism, 4. pantothenate and CoA biosynthesis, 5. pyruvate metabolism, 6. biotin metabolism, 7. glyoxylate and dicarboxylate metabolism, 8. tryptophan metabolism, 9. alanine, aspartate, and glutamate metabolism, 10. aminoacyl-tRNA biosynthesis, 11. valine, leucine, and isoleucine metabolism, 12. beta-alanine metabolism, 13. ascorbate and aldarate metabolism, 14. sphingolipid metabolism, 15. glycolysis and gluconeogenesis, 16. nitrogen metabolism, 17. phenylalanine, tyrosine, and tryptophan biosynthesis, 18. glycine, serine, and threonine metabolism, 19. pyrimidine metabolism, and 20. arginine and ornithine metabolism.