Research Article

LC-MS-Based Metabolic Fingerprinting of Aqueous Humor

Table 3

The list of metabolic pathways to which putatively identified metabolites belong in aqueous humor.

PathwayNumber of metabolites in pathwayNumber of metabolites detected in AH valuePathway impact

Nitrogen metabolism3960.0343240
Aminoacyl-tRNA biosynthesis7580.0224820.05634
Phenylalanine, tyrosine, and tryptophan biosynthesis2740.327930.008
Valine, leucine, and isoleucine biosynthesis2740.218090.06784
Phenylalanine metabolism4550.159790.28993
Taurine and hypotaurine metabolism2030.0597510.35252
Biotin metabolism1120.0734150.13008
Arginine and proline metabolism7760.107560.18287
Pantothenate and CoA biosynthesis2730.829290.18014
Beta-alanine metabolism2830.808690.06625
Glycine, serine, and threonine metabolism4840.0586610.00118
Glyoxylate and dicarboxylate metabolism5040.768780.14716
Tryptophan metabolism7950.225620.18481
Pyrimidine metabolism6040.698730.02251
Alanine, aspartate, and glutamate metabolism2420.314270.20703
Ascorbate and aldarate metabolism4530.231760.11744
Sphingolipid metabolism2520.526650.09061
D-Arginine and D-ornithine metabolism810.777370
Tyrosine metabolism7640.015380.04724
Glycolysis or gluconeogenesis3120.0801310.09576
Pentose phosphate pathway3220.433660.02181
Vitamin B6 metabolism3220.0052520.0303
Glycerolipid metabolism3220.301380.0412
Pyruvate metabolism3220.407180.28201
D-Glutamine and D-glutamate metabolism1110.327930.02674
Methane metabolism3420.759860.01696
Glycosylphosphatidylinositol- (GPI-) anchor biosynthesis1410.489740.0439
Valine, leucine, and isoleucine degradation4020.327930.06442
Sulfur metabolism1810.336730.03307
Citrate cycle (TCA cycle)2010.174270.09024
Caffeine metabolism2110.327930
Selenoamino acid metabolism2210.355010.00321
Thiamine metabolism2410.878810
Lysine biosynthesis3210.859270.09993
Terpenoid backbone biosynthesis3310.829290
Ubiquinone and other terpenoid-quinone biosynthesis3610.015380
Glutathione metabolism3810.560910.03608
Glycerophospholipid metabolism3910.964540.12753
Butanoate metabolism4010.0959180.08516
Nicotinate and nicotinamide metabolism4410.0024840
Histidine metabolism4410.2580.13988
Primary bile acid biosynthesis4710.54410.00822
Lysine degradation4710.592720.14675
Purine metabolism9220.709890.00969
Pentose and glucuronate interconversions5310.740980
Cysteine and methionine metabolism5610.808690.01649
Amino sugar and nucleotide sugar metabolism8810.864130.00265

Pathway impact and p value were obtained from metabolic pathway analysis performed with MetaboAnalyst 3.0.