The Evidence of Cooperative Binding of a Ligand to G4 DNA

Figure 1

Distribution diagram (a) and pure species spectra (b) resolved by deconvolution of . Species fractions calculated as a function of the DNA/ligand molar ratio (;  μmol/L) in accordance with the model: , , shown as dotted lines. Profiles simulated in accordance with a binding model: , , shown as solid lines. , DNA, DNA, and DNA.

(a)

(b)