A Liquid Chromatography-Tandem Mass Spectrometry Method for Evaluation of Two Brands of Enalapril 20 mg Tablets in Healthy Human Volunteers

Table 1

Intra- and interday precision and accuracy data for enalapril and enalaprilat in human plasma ().

	Intraday (within run)				Interday (between runs)
	Mean concentration (ng/ml)	SD	CV (%)	Accuracy (%)	Mean concentration (ng/ml)	SD	CV (%)	Accuracy (%)
Enalapril
LQC (3 ng/ml)	2.834	0.107	3.773	94.458	2.98	0.21		99.27
MQC (100 ng/ml)	100.691	4.08	4.05	100.691	100.68	4.93		100.68
HQC (1600 ng/ml)	161.366	7.169	4.459	100.854	162.48	12.62		101.55
Enalaprilat
LQC (3 ng/ml)	2.876	0.124	4.295	95.861	3.310	0.210		110.34
MQC (100 ng/ml)	98.514	3.816	3.873	98.514	102.224	4.280		102.24
HQC (160 ng/ml)	152.412	4.517	2.964	95.257	162.11	11.43		101.32

LQC: low quality control; MQC: medium quality control; HQC: high quality control.