Research Article
Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals
Table 3
Analytical results for DMSO-d6 soluble fluorinated pharmaceuticals.
| | Compound | Purity (% w/w) | | 19F NMR | HPLC | USP-certificate |
| | Fluorometholone | 95.9 | 100.0 | 100.0 | | Flumazenil | 94.9 | 99.8 | n.p. | | Flunitrazepam (Rohypnol) | 98.8 | 99.8 | n.p. | | Flutamide | 98.2 | n.d. | 98.0–101.0 | | Fluvastatin sodium hydrate | 83.0 | 84.6 | n.p. | | Fluprednidene acetate | 98.1 | 99.7 | n.p. |
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n.p.: not provided, n.d.: not determined.
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