|
| Type of detection platform used | Validation parameters evaluated | e-Liquids (brand and number of samples) | Reference | Comments |
|
| HPLC, PDA, C 18 (150 × 4.6 mm, 5 µm) | LOD, LOQ, linearity, accuracy, and precision | Smoking everywhere (15), Njoy (5), and CIXI (10) | Trehy et al. [12] | 1. Specificity data are not mentioned |
| 2. Although the method uses PDA detector, no information about peak purity is mentioned |
| 3. Chromatographic integration in the chromatograms published by Trehy et al. is improper, which raises concerns over the specificity of the method |
| HPLC, PDA, C 18 (200 × 4.6 mm, 5 µm) | LOD, LOQ, linearity, accuracy, and precision | Refill fluids (75), do it yourself (1) | Davis et al. And cross-reference of Trehy et al. For the HPLC method [11] |
|
| UPLC | Not applicable | e-Liquids (20). Details not mentioned | Etter et al. [17] | Method not validated for analysis of e-liquids |
|
| UPLC, PDA and MS, C 18 | Linearity | e-Liquids (6). Details not mentioned | Meruva et al. And cross-reference of Trehy et al. for the HPLC method [18] | 1. Additional validation details not provided |
| 2. No data about specificity of the method for nicotine in presence of flavoring chemicals |
|
