A Stability Indicating HPLC Assay Method for Analysis of Rivastigmine Hydrogen Tartrate in Dual-Ligand Nanoparticle Formulation Matrices and Cell Transport Medium

Table 4

Intra- and interday repeatability of RHT analysis in NPs matrix, release medium, and cell transport medium.

RHT concentration^a (µg/mL)	RHT in NPs matrix (200x diluted in mobile phase)		RHT in release medium		RHT in cell transport medium
	Intraday RSD^b	Interday RSD^c	Intraday RSD^b	Interday RSD^c	Intraday RSD^b	Interday RSD^c
1	0.69	1.32	0.73	0.64	0.94	1.24
5	0.92	0.92	0.65	1.11	0.51	1.11
10	0.49	1.19	0.35	1.02	0.15	0.95

^aEach concentration was analysed in triplicate (); ^bthe analyses were carried out at 0, 3, and 8 hrs on the same day, and all data were included in the calculation; ^cthe analyses were carried out at days 1 and 2, and all data were included in the calculation.