Research Article

HPLC Method for Quantification of Caffeine and Its Three Major Metabolites in Human Plasma Using Fetal Bovine Serum Matrix to Evaluate Prenatal Drug Exposure

Figure 4

Bland-Altman plot for theobromine (a), paraxanthine (b), theophylline (c), and caffeine (d) plasma concentrations for mother versus newborn samples. Differences between mother-child pairs. Continuous line represents mean of difference between maternal concentration and neonatal concentration for each analyte. Dotted lines represent lower and upper limits of 95% confidence interval. Theb: Theobromine, Par: paraxanthine, Theo: theophylline, and Caf: caffeine.
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