LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Analytes</td><td class="align_center">Parent ion (<i>m</i>/<i>z</i>)</td><td class="align_center">Product ion (<i>m</i>/<i>z</i>)</td><td class="align_center">Collision energy (V)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Dexmedetomidine</td><td class="align_center">201.01</td><td class="align_center">94.90</td><td class="align_center">17</td></tr><tr><td class="align_left">Dezocine</td><td class="align_center">246.19</td><td class="align_center">147.00</td><td class="align_center">18</td></tr><tr><td class="align_left">Midazolam</td><td class="align_center">325.64</td><td class="align_center">290.75</td><td class="align_center">25</td></tr><tr><td class="align_left">IS</td><td class="align_center">293.20</td><td class="align_center">237.08</td><td class="align_center">13</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The optimized mass spectrometric parameters for dexmedetomidine, dezocine, midazolam, and IS.</div>

Journal of Analytical Methods in Chemistry

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Table 1

Table 1: LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study 

Table 1 | LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study 