Research Article

Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MS/MS after Oral Administration of Drynariae rhizoma Extract

Table 5

Stability evaluation results ().

AnalytesSpiked (ng/ml)Autosampler (4°C, 36 h)Long-term (−20°C, 30 days)Freeze-thaw (−20°C-room temperature)
MeasuredRE (%)MeasuredRE (%)MeasuredRE (%)

Neoeriocitrin40.440.29 ± 1.99−1.0040.5 ± 2.82−1.2139.8 ± 1.92−2.92
202198.79 ± 11.222.58206.55 ± 12.41.72205.16 ± 23.241.36
20202001.91 ± 21.3−0.902012.25 ± 27.81−0.372032.19 ± 45.280.61
Luteolin-7-O-β-D-glucoside5.045.02 ± 0.18−3.124.99 ± 0.07−2.345.01 ± 0.21−1.26
50.449.44 ± 1.55−1.3849.37 ± 3.07−3.6449.55 ± 8.55−2.45
504494.39 ± 10.55−1.90493.07 ± 13.07−2.16491.55 ± 18.55−2.47
Astragalin5.15.02 ± 0.18−1.634.99 ± 0.07−2.185.01 ± 0.21−1.79
102101.10 ± 4.29−2.7999.7 ± 3.76−4.13102.04 ± 4−1.88
10201006.41 ± 30.283.561002.46 ± 35.151.221000.65 ± 34.591.04
Naringin10.210.5 ± 0.14−4.0210.3 ± 0.09−0.279.9 ± 0.18−1.11
408401.01 ± 8.13−0.24400.90 ± 9.65−0.51403.52 ± 11.42−0.11
61206008.15 ± 38.45−5.666010.28 ± 22.59−3.226009.12 ± 43.76−4.99
Eriodictyol1.020.96 ± 0.06−1.301.06 ± 0.06−4.220.99 ± 0.07−2.84
40.838.83 ± 2.5−0.4439.87 ± 1.832.2839.00 ± 2.32−2.64
816834.09 ± 23.38−0.70837.06 ± 26.59−0.34824.21 ± 18.77−1.88
Luteolin10.110.2 ± 0.043.549.97 ± 0.09−0.139.96 ± 0.1−1.04
40.437.85 ± 1.420.9438.08 ± 1.51.5539.39 ± 1.9−0.29
10101000.91 ± 21.3−1.911006.25 ± 27.81−0.251016.19 ± 45.280.64
Naringenin5.25.1 ± 0.060.925.1 ± 0.110.895.08 ± 0.110.66
41.641.50 ± 3.05−1.2041.33 ± 3.09−1.6041.13 ± 3.11−2.06
208207.10 ± 4.29−4.79208.70 ± 5.76−8.13204.04 ± 8−3.76
Kaempferol1.061.05 ± 0.14−3.021.03 ± 0.09−0.491.09 ± 0.18−1.71
42.440.59 ± 1.39−1.0741.15 ± 2.32−1.3441.8 ± 1.58−2.67
424419.01 ± 7.42−0.44427.9 ± 3.74−0.46419.52 ± 8.323−0.31