NMR, Novel Pharmacological and In Silico Docking Studies of Oxyacanthine and Tetrandrine: Bisbenzylisoquinoline Alkaloids Isolated from Berberis glaucocarpa Roots

Table 1

¹H NMR (400 MHz) and ¹³C NMR (100 MHz) data of compound 1 (CDCl₃).

Position	δH in ppm (mult., J in Hz)	δC in ppm	Position	δH in ppm (mult., J in Hz)	δC in ppm
1	3.76, (m)	63.71	1/	3.78, (m)	62.20
N-Me	2.22, (s)	42.70	N/-Me	2.51, (s)	42.75
3	2.85 and 3.39, (m)	45.87	3/	2.54 and 2.97, (m)	44.89
4	2.75 and 2.90, (m)	25.46	4/	2.79 and 2.89, (m)	22.69
4a	—	128.10	4/a	—	127.41
5	6.24, (br. s)	105.46	5/	6.49, (s)	111.23
6	—	151.81	6/	—	149.90
7	—	136.95	7/	—	143.76
6-OMe	3.72, (s)	55.53	6/-OMe	3.55, (s)	55.77
7-OMe	3.08, (s)	60.50
8	—	147.53	8/	5.95, (br.s)	119.84
8a	—	120.74	8/a	—	128.74
α	2.78 and 3.24, (m)	38.56	α/	2.79 and 3.26, (m)	37.77
9	—	133.51	9/	—	135.57
10	6.38, (br. s)	114.67	10/	6.40 (dd, 8.6, 2.4)	121.38
11	—	143.53	11/	6.58, (dd, 8.6, 2.4)	121.73
12	—	148.18	12/	—	153.82
13	6.78, (d, 7.4)	115.30	13/	7.08, (dd, 8.6, 2.4)	130.25
14	6.71, (dd, 7.4, 2.2)	123.52	14^/	7.25, (dd, 8.6, 2.4)	132.25