One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS

<div>Representative MRM chromatograms of paclitaxel (A), docetaxel (B), vinblastine (C), vinorelbine (D), pemetrexed (E), carboplatin (F), etoposide (G), cyclophosphamide (H), ifosfamide (I), gemcitabine (J), irinotecan (K), SN-38 (L), and vindoline (M, IS). (a) Blank plasma sample, (b) blank plasma sample spiked with twelve analytes at LLOQ and IS, and (c) plasma sample collected from a patient at 6 h after administration of etoposide and ifosfamide at general dose.</div>

Journal of Analytical Methods in Chemistry

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Figure 2: One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS 

Figure 2 | One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS 