One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS

Table 1

Optimized multiple reaction monitoring parameters for the analytes and IS.

Analyte	Precursor ion	Fragmentor energy (V)	Collision energy (eV)	Production ion
Paclitaxel	876.4	250	30	308.0
Docetaxel	830.4	200	20	303.9
Vinblastine	811.5	200	50	224.2
Vinorelbine	779.3	350	40	122.1
Pemetrexed	428.3	80	10	281.2
Carboplatin	372.2	80	10	294.1
Etoposide	589.0	150	10	229.1
Cyclophosphamide	261.1	80	14	140.0
Ifosfamide	261.1	80	20	154.0
Gemcitabine	264.2	80	10	112.1
Irinotecan	587.3	200	40	124.1
SN-38	393.2	150	30	349.1
Vindoline (IS)	457.3	150	20	188.1