One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS

Table 3

Matrix effect and recovery of the analytes ().

Analyte	Nominal concentration (ng/mL)	Extraction recovery		Matrix effect
		Mean (%)	RSD (%)	Mean (%)	RSD (%)
Paclitaxel	50.0	60.8	9.5	90.5	6.4
	250.0	66.1	7.2	90.3	3.5
	1250.0	62.3	6.8	92.4	3.7
Docetaxel	20.0	88.2	5.6	91.2	8.8
	100.0	87.3	6.8	89.7	6.4
	500.0	85.5	5.4	92.0	7.1
SN-38	20.0	64.1	7.9	97.3	4.3
	100.0	74.3	6.7	94.3	6.5
	500.0	72.5	5.4	101.9	5.2
Vinorelbine	200.0	69.4	7.9	96.1	1.4
	1000.0	74.6	5.4	101.3	2.1
	5000.0	70.9	7.1	94.9	3.7
Pemetrexed	200.0	70.7	6.0	93.8	6.0
	1000.0	67.7	5.4	99.6	5.8
	5000.0	73.5	5.9	93.4	5.6
Vinblastine	50.0	66.2	11.3	85.2	7.9
	500.0	77.3	9.8	85.7	8.4
	5000.0	80.1	3.8	87.9	4.2
Irinotecan	50.0	60.7	6.6	96.5	9.0
	500.0	64.2	5.9	98.5	8.1
	5000.0	75.1	6.0	97.7	7.4
Cyclophosphamide	5.0	89.9	6.2	82.2	9.9
	50.0	90.1	3.8	90.6	11.3
	500.0	98.9	3.4	90.0	4.4
Ifosfamide	5.0	72.1	5.6	99.1	11.2
	50.0	74.3	2.9	99.5	10.5
	500.0	76.6	4.8	98.0	7.6
Carboplatin	100.0	88.3	8.1	98.0	7.4
	500.0	72.9	4.7	99.7	5.1
	2500.0	72.9	4.9	95.0	7.6
Etoposide	100.0	70.1	6.3	96.9	5.5
	500.0	65.6	8.5	93.7	2.9
	2500.0	64.1	4.9	76.4	4.9
Gemcitabine	100.0	80.8	7.3	99.8	10.6
	500.0	79.3	3.2	99.9	9.8
	2500.0	70.6	8.3	96.3	7.2
IS	100.0	92	5.8	95.7	6.8