One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS

Table 4

Regression curves and parameters of the analytes ().

Analyte	Linearity range (ng/mL)			R^2	LLOQ (ng/mL)	LOD (ng/mL)
		a	b
Paclitaxel	25.0–2500.0	0.0279	−0.0055	0.9907	25.0	10.0
Docetaxel	10.0–1000.0	0.0109	−0.0008	0.9963	10.0	2.0
SN-38	10.0–1000.0	1.7720	−0.1020	0.9956	10.0	1.0
Vinorelbine	100.0–10000.0	0.2455	−0.2388	0.9939	100.0	50.0
Pemetrexed	100.0–10000.0	0.3559	−0.2553	0.9911	100.0	50.0
Vinblastine	10.0–10000.0	0.6351	−0.0367	0.9944	10.0	2.0
Irinotecan	10.0–10000.0	3.1941	−0.3255	0.9942	10.0	3.0
Cyclophosphamide	1.0–1000.0	3.8840	−0.0072	0.9957	1.0	0.5
Ifosfamide	1.0–1000.0	7.2394	−0.0113	0.9951	1.0	0.5
Carboplatin	50.0–5000.0	0.0388	−0.0046	0.9974	50.0	25.0
Etoposide	50.0–5000.0	0.2673	−0.1549	0.9936	50.0	25.0
Gemcitabine	50.0–5000.0	1.1805	1.1461	0.9919	50.0	25.0