Analytical Method Development and Validation for the Quantification of Acetone and Isopropyl Alcohol in the Tartaric Acid Base Pellets of Dipyridamole Modified Release Capsules by Using Headspace Gas Chromatographic Technique

Table 1

Chromatographic parameters.

Column	Fused silica DB-624 (30 m × 0.32 mm × 1.8 µm)	Makeup gas flow	25 mL/minute
Detector	Flame ionization detector (FID)	Oven temperature	40°C for 10 minutes and increasing the temperature to 210°C at the rate of 35°C/minute and kept for 5 minutes
Mode	Constant flow	Headspace sampler condition
Carrier gas	Nitrogen	Oven temperature	80°C
Front Injector condition		Loop temperature	90°C
Inject temperature	140°C	Transfer line temperature	100°C
Carrier gas flow	1.0 mL/min	GC cycle time	34 minutes
Split ratio	20 : 1	Vial equilibration time	20 minutes
Injector type	Split	Pressurization time	1.0 minutes
Front detector condition		Loop fill time	0.2 minutes
Detector temperature	260°C	Loop equilibration time	0.05 minutes
Hydrogen flow	30 mL/minute	Injection time	1.0 minutes
Air flow	300 mL/minute	Shake	High