Research Article
Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood
Table 2
Pharmacokinetic parameters after delsoline administration in mice.
| | Parameters | Unit | ig (9 mg/kg) | ig (6 mg/kg) | ig (3 mg/kg) | iv (1 mg/kg) |
| | AUC(0–t) | ng/mLh | 570.1 ± 147.5 | 271.9 ± 25.5 | 128.4 ± 52.2 | 241.4 ± 43.9 | | AUC(0–∞) | ng/mLh | 571.0 ± 147.5 | 272.9 ± 25.1 | 129.9 ± 51.4 | 242.4 ± 44.0 | | MRT(0–t) | H | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.1 ± 0.2 | 0.3 ± 0.1 | | MRT(0–∞) | H | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.2 ± 0.3 | 0.4 ± 0.1 | | t1/2z | H | 1.3 ± 0.5 | 1.6 ± 0.7 | 1.7 ± 0.8 | 2.5 ± 0.7 | | CLz/F | L/h/kg | 16.7 ± 4.4 | 22.1 ± 1.9 | 25.6 ± 8.3 | 4.2 ± 0.8 | | Vz/F | L/kg | 33.1 ± 22.7 | 51.1 ± 23.0 | 67.8 ± 50.3 | 15.4 ± 4.5 | | Cmax | ng/mL | 573.2 ± 124.9 | 381.8 ± 70.8 | 146.0 ± 56.8 | 505.3 ± 69.5 | | Bioavailability | | 26.2% | 18.8% | 17.7% | |
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