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Journal of Analytical Methods in Chemistry
Volume 2018, Article ID 9470254, 9 pages
Research Article

Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets

1Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Republic of Korea
2Department of Environmental Science and Engineering, Ewha Womans University, Seoul 03759, Republic of Korea
3Department of Chemical Engineering and Material Science, Ewha Womans University, Seoul 03760, Republic of Korea
4Department of Health, Environment & Safety, Eulji University, Seongnam 13135, Republic of Korea
5Seoul Center, Korea Basic Science Institute, Seoul 02841, Republic of Korea
6Institute of Mine Reclamation Technology, Mine Reclamation Corporation, Wonju 26464, Republic of Korea

Correspondence should be addressed to Yun Gyong Ahn;

Received 31 August 2017; Revised 26 November 2017; Accepted 7 December 2017; Published 5 February 2018

Academic Editor: Paolo Montuori

Copyright © 2018 So Hyeon Jeon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8–122% with the relative standard deviations of 1.8–17.8%. The limits of quantification (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.