Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Mix.</td><td class="align_center" rowspan="2">Dosage form</td><td class="align_center" rowspan="2">Component</td><td class="align_center" rowspan="2">Actual conc. (<i>μ</i>g/mL)</td><td class="align_center" colspan="2">PCR</td><td class="align_center" colspan="2">PLS</td></tr><tr class="thead"><td class="align_center">Predicted (<i>μ</i>g/mL ± SD)</td><td class="align_center">% recovery</td><td class="align_center">Predicted (<i>μ</i>g/mL ± SD)</td><td class="align_center">% recovery</td></tr><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr><td class="align_left" rowspan="2">Mix. 1</td><td class="align_center">Tablet</td><td class="align_center">CIP</td><td class="align_center">8</td><td class="align_center">7.94 ± 0.064</td><td class="align_center">99.19</td><td class="align_center">7.94 ± 0.065</td><td class="align_center">99.25</td></tr><tr><td class="align_center">Capsule</td><td class="align_center">DOX</td><td class="align_center">12</td><td class="align_center">12.13 ± 0.548</td><td class="align_center">101.08</td><td class="align_center">12.13 ± 0.560</td><td class="align_center">101.08</td></tr><tr><td class="align_left" colspan="8"><hr/></td></tr><tr><td class="align_left" rowspan="2">Mix 2</td><td class="align_center">Tablet</td><td class="align_center">CIP</td><td class="align_center">8</td><td class="align_center">7.90 ± 0.039</td><td class="align_center">98.75</td><td class="align_center">7.91 ± 0.041</td><td class="align_center">98.81</td></tr><tr><td class="align_center">Tablet</td><td class="align_center">DOX</td><td class="align_center">12</td><td class="align_center">11.74 ± 0.974</td><td class="align_center">97.79</td><td class="align_center">11.74 ± 0.041</td><td class="align_center">97.79</td></tr><tr class="table-tr"><td colspan="8"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

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Journal of Analytical Methods in Chemistry

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Table 4

Table 4: Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations 

Table 4 | Chemometric-Assisted Spectrophotometric Method for the Simultaneous Determination of Ciprofloxacin and Doxycycline Hyclate in Pharmaceutical Formulations 