Simultaneous Assay of Dexchlorpheniramine Maleate, Betamethasone, and Sodium Benzoate in Syrup by a Reliable and Robust HPLC Method
Table 7
Results of repeatability and intermediate precision.
No. of sample solution
Sample weight (g) Density: 1.095 g/mL
Content of dexchlorpheniramine maleate in syrup (%, comparing to labeled amount)
Content of sodium benzoate in syrup (%, comparing to labeled amount)
Content of betamethasone in syrup (%, comparing to labeled amount)
Day 1, analyst 1
1
5.4324
101.0
101.2
101.5
2
5.4630
100.4
100.5
101.3
3
5.3981
100.7
101.1
101.6
4
5.5087
99.0
99.2
99.8
5
5.4672
100.0
100.2
100.2
6
5.5064
98.6
98.8
99.5
Average (1–6)
99.9
100.2
100.7
RSD (%) (1–6)
1.0
1.0
0.9
Day 2, analyst 2
7
5.5623
99.6
101.2
101.5
8
5.4786
101.4
100.5
101.3
9
5.5368
100.2
101.1
101.6
10
5.4361
101.7
99.2
99.8
11
5.5698
100.1
100.2
100.2
12
5.5345
100.1
98.8
99.5
Average (1–12)
100.2
99.5
101.2
RSD (%) (1–12)
0.9
1.1
1.0
Results obtained in day 1 by analyst 1 (sample no. 1–6) were used for evaluating repeatability and those obtained in day 1 and day 2 (sample no. 1–12) were used together for evaluating intermediate precision.
