Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Method

Figure 3

Representative chromatograms of pemetrexed disodium (A), gemcitabine hydrochloride (B) and IS (C) in rat plasma at 268 nm. Chromatographic profile of (a) a blank plasma sample, (b) a sample of plasma spiked with analytes and IS, and (c) a sample of plasma at 2 min after intravenous administration of gemcitabine.

(a)

(b)

(c)