Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left">Product</td><td class="align_center">Manufacture</td><td class="align_center">Batch number</td><td class="align_center">Strength</td><td class="align_center">Recommended upper limit daily dosage</td><td class="align_center">Limit of PGIs based on 1.5 <i>μ</i>g/day</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">Amlodipine besylate tablet</td><td class="align_center">Pfizer Inc. (NY, NY, USA)</td><td class="align_center">20170520</td><td class="align_center">5 mg</td><td class="align_center">10 mg</td><td class="align_center">150 <i>μ</i>g/g</td></tr><tr><td class="align_left">Phentolamine mesylate tablet</td><td class="align_center">Beijing Shuguang Pharmaceutical Industrial Co., Ltd. (Beijing, China)</td><td class="align_center">170215</td><td class="align_center">40 mg</td><td class="align_center">60 mg</td><td class="align_center">25 <i>μ</i>g/g</td></tr><tr><td class="align_left">Tosufloxacin tosylate tablet</td><td class="align_center">Chifeng Wanze Pharmaceutical Co., Ltd. (Chifeng, Neimenggu, China)</td><td class="align_center">170524</td><td class="align_center">0.15 g</td><td class="align_center">0.6 g</td><td class="align_center">2.5 <i>μ</i>g/g</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Journal of Analytical Methods in Chemistry

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Table 1

Table 1: Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS 

Table 1 | Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS 