Research Article
Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets
Table 2
The obtained results of the dissolution test of metformin 1000 mg film-coated tablets using different apparatus and volume of the medium.
| | Phosphate buffer pH 6.8 | Case 1: metformin 1000 mg film-coated tablets basket, 100 rpm, 900 mL | Case 2: metformin 1000 mg film-coated tablets basket, 100 rpm, 1000 mL | Case 3: metformin 1000 mg film-coated tablets paddle, 75 rpm, 1000 mL |
| Time | 5 | 10 | 15 | 20 | 30 | 45 | 5 | 10 | 15 | 20 | 30 | 45 | 5 | 10 | 15 | 20 | 30 | 45 | Average | 27.33 | 47.52 | 65.38 | 76.34 | 90.85 | 95.55 | 34.50 | 59.62 | 78.12 | 89.08 | 96.40 | 96.13 | 36.55 | 61.31 | 81.10 | 93.24 | 97.51 | 98.17 | RSD | 10.13 | 11.07 | 11.30 | 9.48 | 4.46 | 1.71 | 9.89 | 8.97 | 7.72 | 7.07 | 1.63 | 2.69 | 7.72 | 6.18 | 3.00 | 2.55 | 0.45 | 1.48 | Min | 25.11 | 43.02 | 56.90 | 67.33 | 83.79 | 92.37 | 28.45 | 49.83 | 66.42 | 78.44 | 93.31 | 91.14 | 32.78 | 56.85 | 78.19 | 90.29 | 97.07 | 96.39 | Max | 34.54 | 61.13 | 82.38 | 92.81 | 96.36 | 99.07 | 37.24 | 64.93 | 83.54 | 94.14 | 97.78 | 98.47 | 39.96 | 66.66 | 84.75 | 96.25 | 98.25 | 100.82 |
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