Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extracts

Table 1

Precursor/production pairs and parameters for MRM of ginsenosides.

Analytes	Ionization mode	[M-H]^−(m/z)	MRM transitions (precursor-product)	Cone voltage (V)	Collision energy (eV)
Rb1	Negative	1107.5	1107.5 ⟶ 621.2	80	40
			1107.5 ⟶ 459.6		45
Rb2	Negative	1077.7	1077.7 ⟶ 621.5	80	50
			1077.7 ⟶ 459.5		60
Rd	Negative	945.5	945.5 ⟶ 621.5	85	50
			945.5 ⟶ 459.5		45
Re	Negative	945.5	945.5 ⟶ 637.5	80	45
			945.5 ⟶ 475.5		40
Dioscin	Negative	867.6	867.6 ⟶ 721.0	85	45

Quantitative ion.