Comparative Pharmacokinetic Studies of Four Ginsenosides in Rat Plasma by UPLC-MS/MS after Oral Administration of Panax quinquefolius-Acorus gramineus and Panax quinquefolius Extracts

Table 6

Pharmacokinetic parameters of the ginsenosides after oral administration of PQ-AG and PQ extracts in rats (n = 6, mean ± SD).

Group	Compounds	Cmax (ng/mL)	Tmax (h)	t1/2 (h)	AUC0⟶t (ng·h/mL)	AUC0⟶∞ (ng·h/mL)
PQ-AG	Rb1	600.2 ± 53.6	6.67 ± 1.03	18.52 ± 2.61	8132.09 ± 454.40	8414.43 ± 487.69
	Rb2	264.1 ± 24.5	7.67 ± 0.82	15.61 ± 5.21	2458.74 ± 242.86	2518.20 ± 288.99
	Rd	283.4 ± 11.1	6.33 ± 0.82	14.21 ± 1.98	3874.28 ± 356.39	3955.23 ± 382.94
	Re	460.4 ± 30.2	0.58 ± 0.20	9.81 ± 2.15	3427.96 ± 293.76	3582.89 ± 396.42
PQ	Rb1	461.2 ± 15.9	7.00 ± 1.10	15.61 ± 1.52	5983.67 ± 313.47	6146.74 ± 328.31
	Rb2	160.1 ± 18.8	7.67 ± 0.82	13.34 ± 1.58	1214.41 ± 99.25	1229.91 ± 99.58
	Rd	200.9 ± 7.3	7.67 ± 0.82	13.11 ± 2.61	3005.92 ± 229.63	3324.67 ± 317.05
	Re	354.7 ± 26.6	1.08 ± 0.20	8.14 ± 1.20	2331.52 ± 214.10	2379.76 ± 223.68

compared with PQ group.