Research Article

The Application and Analytical Pathway of Dexmedetomidine in Ischemia/Reperfusion Injury

Figure 5

Dexmedetomidine inhibited autophagy and mitophagy through suppressing MCU after OGD/R injury. (a) Comparison of the expression of Bcl-2, beclin 1, P62, LC3, and TOM20 by Western blot. (b–f) The results of Western blot showed that dexmedetomidine downregulated the activation of autophagy and that mitophagy was reversed by spermine after OGD/R. , compared with the control group; , compared with the OGD/R group; , compared with the DEX group; , compared between the two indicated groups. Data were recorded as mean ± SD, n = 3.