Preconcentration and Determination of Psychotropic Drugs in Urine Samples by Ion Mobility Spectrometry with Electrospray Ionization Coupling On-Line Single-Drop Liquid-Liquid-Liquid Microextraction

Table 2

Ion responses of ketamine and pethidine in the TIM and WIM with different solvents.

Solvent	PI	Ketamine ion responses
		TIM		WIM
		Mean	Standard deviation	Mean	Standard deviation
Dodecane	0.1	8540	314	2430	223
Isooctane	0.2	8170	280	2340	222
Cyclohexane	0.2	6230	261	1850	120
Hexane	0.1	5800	153	1780	220
Toluene	2.4	—	3210	136
Xylene	2.6	—	3030	285
1-Octanol	3.4	—	1620	158
Dodecane	0.1	6160	233	1570	124
Isooctane	0.2	6050	227	1380	101
Cyclohexane	0.2	1080	100	370	48
Hexane	0.1	2430	281	590	149
Toluene	2.4	—	2570	199
Xylene	2.6	—	2230	171
1-Octanol	3.4	—	1270	192

PI: polarity index.