Fingerprint Spectrophotometric Methods for the Determination of Co-Formulated Otic Solution of Ciprofloxacin and Fluocinolone Acetonide in Their Challengeable Ratio
Table 1
Selection of the best divisor of (CIP) and FLU by the optimization study.
Mix no.
(CIP) divisors
4.0 μg/mL
8.0 μg/mL
12.0 μg/mL
Post
Rec
Post
Rec
Post
Rec
1
1.250
1.277
0.625
0.632
0.417
0.422
2
2.500
2.545
1.250
1.259
0.833
0.842
3
1.000
1.020
0.500
0.537
0.333
0.326
4
1.000
1.028
0.500
0.503
0.333
0.331
5
2.000
2.044
1.000
0.980
0.667
0.645
AAD
0.033
0.015
0.009
Mix no.
FLU divisors
4.0 μg/mL
8.0 μg/mL
12.0 μg/mL
Post
Rec
Post
Rec
Post
Rec
1
1.250
1.352
0.625
0.635
0.417
0.421
2
1.000
1.041
0.500
0.488
0.333
0.343
3
2.500
2.452
1.250
1.271
0.833
0.845
4
2.000
2.013
1.000
1.002
0.667
0.668
5
1.000
1.018
0.500
0.482
0.333
0.331
AAD
0.044
0.013
0.006
The values represent the constant at the plateau regions (300.0–330.0 nm) for (CIP) and (220.0–260.0 nm) for FLU. Post: postulated value of constant; Rec: recorded value of constant; AAD: average absolute difference between postulated and recorded constant values.
