A Sensitive and Efficient Method for Determination of Capecitabine and Its Five Metabolites in Human Plasma Based on One-Step Liquid-Liquid Extraction

Figure 1

The metabolic pathways and targets of Cap. Cap: capecitabine; 5’-DFCR: 5’-deoxy-5-fluorocytidine; 5’-DFUR: doxifluridine; 2’-DFUR: 5-fluoro-2’-deoxyuridine; 5-FU: 5-fluorouracil; FUH2: dihydrofluorouracil; FBAL: α-fluoro-β-alanine; CES: carboxylesterase; CDA: cytidine deaminase; TP: thymidylate phosphorylase; TS: thymidylate synthetase; FUMP: fluorouridine monophosphate; FUTP: fluorouridine triphosphate; FdUTP: deoxyfluorouridine triphosphate; FdUMP: deoxyfluorouridine monophosphate.