Pharmacokinetic and Lipidomic Assessment of the In Vivo Effects of Parishin A-Isorhynchophylline in Rat Migraine Models

Table 1

Pharmacokinetic parameters of the determining compounds.

Parameters	Unit	ISO		RHY		GAS		PA
		Single	Combine	Single	Combine	Single	Combine	Single	Combine
AUC (0 − t)	μg/L  h	1340.01	1755.85	313.95	412.82	9934.28	12757.67	0.00	304.22
AUC (0 − ∞)	μg/L  h	1340.09	1768.51	314.00	455.57	9935.51	13028.09	0.00	304.22
MRT (0 − t)	h	1.76	1.98	3.21	4.90	2.14	3.95	0.00	4.58
MRT (0 − ∞)	h	1.77	2.34	3.21	8.57	2.15	4.36	0.00	4.58
t1/2z	h	1.90	3.79	1.63	5.64	1.02	2.85	0.00	0.69
T-max	h	0.54	0.58	0.63	0.96	0.83	1.08	0.00	1.99
V z/F	L/kg	241.72	174.09	663.02	614.92	56.61	110.10	0.00	1177.20
CL z/F	L/h/kg	88.98	28.16	331.66	104.87	38.38	29.90	0.00	8247.98
C-max	μg/L	645.28	867.07	88.35	94.10	4082.17	3853.50	0.00	114.42