Sensitive Quantification of Liensinine Alkaloid Using a HPLC-MS/MS Method and Its Application in Microvolume Rat Plasma

Table 6

Main pharmacokinetic parameters of liensinine after oral administration at three escalating doses (mean ± SD, n = 5).

Pharmacokinetic parameters	Dose (mg/kg)
	5.0	12.5	25.0
AUC0–t (ng h/ml)	60.97 ± 6.91	224.64 ± 60.73	780.56 ± 70.05
AUC0–∞ (ng h/ml)	81.92 ± 22.79	279.25 ± 83.77	881.90 ± 106.59
T1/2 (h)	12.72 ± 6.61	11.05 ± 2.49	11.08 ± 4.25
MRT0–∞ (h)	16.95 ± 7.3	13.89 ± 1.55	12..36 ± 2.35
Vz (L/Kg)	64.42 ± 15.84	62.77 ± 24.50	57.57 ± 19.60
CLz (L/h/Kg)	3.89 ± 1.12	3.93 ± 1.20	3.69 ± 0.42
Cmax (μg/L)	6.70 ± 1.32	33.66 ± 12.48	154.74 ± 17.94
F (%)	5.98	8.16	12.88