A Fast and Validated HPLC Method for Simultaneous Determination of Dopamine, Dobutamine, Phentolamine, Furosemide, and Aminophylline in Infusion Samples and Injection Formulations

Table 6

Mean concentrations of DPM, DBM, PTM, FSM, and APL in 0.9% sodium chloride injection with light protection or light exposure at 25°C.

Storage conditions	Time (hours)	DPM	DBM	PTM	FSM	APL
Light protection	0	100.0 ± 1.3	100.0 ± 1.0	100.0 ± 0.6	100.0 ± 0.8	100.0 ± 1.4
	2	102.5 ± 1.9	100.3 ± 0.4	97.6 ± 2.2	100.1 ± 0.3	100.6 ± 0.2
	4	102.5 ± 0.8	99.8 ± 1.2	100.0 ± 0.2	98.7 ± 1.1	98.9 ± 1.1
	8	102.8 ± 0.4	101.7 ± 0.7	99.9 ± 0.4	98.8 ± 0.5	100.7 ± 0.9
	24	103.0 ± 0.5	100.9 ± 0.6	101.9 ± 1.1	99.7 ± 0.2	100.5 ± 0.5
	48	103.2 ± 1.4	99.1 ± 1.2	100.5 ± 0.8	97.8 ± 1.1	98.6 ± 0.4
Light exposure	0	100.0 ± 1.1	100.0 ± 0.4	100.0 ± 0.7	100.0 ± 0.2	100.0 ± 0.6
	2	102.0 ± 0.4	101.2 ± 0.9	100.9 ± 1.0	99.1 ± 0.4	100.7 ± 1.3
	4	102.2 ± 0.5	103.0 ± 2.3	99.8 ± 0.2	99.3 ± 0.7	101.0 ± 1.2
	8	101.5 ± 1.3	100.7 ± 0.8	100.6 ± 0.3	98.1 ± 1.0	97.7 ± 2.0
	24	101.8 ± 0.3	100.2 ± 0.5	97.6 ± 0.2	99.2 ± 0.8	98.9 ± 0.3
	48	102.3 ± 1.8	98.1 ± 1.4	96.2 ± 1.4	98.3 ± 1.3	98.4 ± 1.0