Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies

Figure 3

Representative chromatograms of apremilast and its IS in (A) blank beagle dog plasma spiked with working solutions at 2 ng mL⁻¹ of apremilast and 100 ng L⁻¹ of IS and (B) beagle dog plasma samples collected at 0.5 h after oral administration of apremilast at 30 mg·day⁻¹.

(A)

(B)