Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population

Table 2

Pharmacokinetic parameters of 50 mg TLN after administration to healthy Egyptian volunteers (n = 6).

Pharmacokinetic parameters	Trelagliptin
Cmax (nMol/L) as mean ± S.D. Cmax (highest value–lowest value)	629.23 ± 57.04 (695.47–560.63)
Cmax (ng/mL) as mean ± S.D. Cmax (highest value–lowest value)	225.37 ± 20.43 (249.09–200.80)
Tmax (hours) as mean ± S.D. Tmax (highest value–lowest value)	1.1 ± 0.34 (1.5–0.5)
Elimination rate constant (h^−1) as mean ± S.D. (highest value–lowest value)	0.046353 ± 0.004213 (0.0498422 and 0.0375328)
t1/2(0-96) (hours) as mean ± S.D. (highest value–lowest value)	15.1 ± 1.6 (18.5 and 14.0)
AUC 0-t (nMolh/L) as mean ± S.D. (t = 96)	9827.2 ± 1075.8
AUC 0-inf (nMolh/L) as mean ± S.D.	9982.5 ± 1027.4
AUC 0-t (ngh/mL) as mean ± S.D. (t = 96)	3519.8 ± 385.3
AUC 0-inf (ngh/mL) as mean ± S.D.	3575.4 ± 368.0