LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study

Table 6

Blood pharmacokinetic parameters of HCQ and its three metabolites in rat (n = 5).

Parameters	HCQ	DCQ	DHCQ	BDCQ
T1/2 (h)	21.14  ±  10.31	108.63  ±  82.06	109.82  ±  46.38	110.98  ±  43.54
CL (L/h/kg)	1.52  ±  0.38	1.24  ±  0.54	0.32 ± 0.07	3.39  ±  0.38
AUC0 ⟶ t (μg/)	30515.35  ±  3038.99	14464.13  ±  2068.53	40723.45  ±  5804.73	3257.60  ±  234.57
AUC0 ⟶ ∞ (μg/)	42774.94  ±  8495.26	34880.13  ±  17962.93	118353.55  ±  27515.19	10744.56  ±  1248.49
Tmax (h)	4.00  ±  2.83	10.40  ±  2.20	72.00  ±  33.94	96.00  ±  0.00
Cmax (μg/L)	1440.72  ±  298.24	331.83  ±  49.45	551.40  ±  83.66	49.60  ±  6.11