Journal of Analytical Methods in Chemistry

Advances in MS-Based Analytical Methods: Innovations and Future Trends


Status
Published

1University of Parma, Parma, Italy

2Stockholm University, Stockholm, Sweden

3University of Urbino, Urbino, Italy

4Spanish National Research Council (IIM-CSIC), Vigo, Spain


Advances in MS-Based Analytical Methods: Innovations and Future Trends

Description

Mass spectrometry is the most specific technique for the detection and identification of organic and inorganic compounds. It is able to provide molecular weight information as well as a wealth of structural details that together give a unique fingerprint for each sample. It is used widely in analytical laboratories for academic research, industrial product development, and regulatory compliance with particular importance in proteomics, drug discovery, environmental monitoring, food regulation, and forensic and homeland security. Due to these characteristics, MS-based analytical methods are showing an increasing interest in the scientific community, where the identification of unknown compounds in complex matrices represents a key parameter. The advent of ambient MS technology paved the way for the development of a great variety of applications and innovations: the challenge of analyzing samples in their native state encouraged the development of new ion sources like desorption electrospray ionization (DESI), direct analysis in real time (DART), or paper spray ionization (PSI). Miniaturized mass spectrometers have been recently introduced to improve portability and accessibility in order to promote in-field and real-time analyses. Novel materials and new instrumental configurations are under study to enhance the performance of different ion sources; additional dimension for separation using ion mobility has been proposed for the analyses of complex mixtures. Safety issues can be identified at the early stages through nontargeted monitoring technologies. Furthermore, the variety of fragmentation strategies that can be combined in new instrumentation overall enhances work in the OMICS fields, particularly proteomics and metabolomics. Mass spectrometric imaging is another emerging powerful analytical technique that has been applied to perform parallel analyses of multiple molecules in complex samples without labeling, thus providing a distinct advantage over preexisting methods for label-free and simultaneous detection of drugs and metabolites. Although MS-based methods are getting progressively more powerful, more reliable, and easily available, the main drawbacks are still related to sample complexity and preparation, mass accuracy, and the need of high-throughput and screening analyses when a great number of samples have to be analyzed.

The aim of the proposed special issue is to cover the aspects regarding emerging features of MS-based techniques. Innovative studies on advances in MS are welcome: submission of papers dealing with the development of prototypes, new instrumental configurations, and MS-based methods, in which new approaches of environmental, food, clinical, or forensic concern are described, is encouraged. The role of MS innovations should be clearly pointed out.

Potential topics include but are not limited to the following:

  • New materials for MS-based analyses
  • New MS instrumentation and approaches
  • MS-based analytical methods for forensic applications
  • MS-based methods for biomarker disease/drug discovery
  • MS-based methods for food security and food safety
  • MS-based methods for environmental analysis
  • MS-based methods in the cultural heritage field
  • Ambient MS
  • Imaging MS

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 2084567
  • - Editorial

Advances in MS-Based Analytical Methods: Innovations and Future Trends

Federica Bianchi | Leopold Ilag | ... | Lucia Mendez
  • Special Issue
  • - Volume 2018
  • - Article ID 4142527
  • - Review Article

New Advances in Toxicological Forensic Analysis Using Mass Spectrometry Techniques

Noroska Gabriela Salazar Mogollón | Cristian Daniel Quiroz-Moreno | ... | Fabio Augusto
  • Special Issue
  • - Volume 2018
  • - Article ID 7019204
  • - Research Article

Establishing Analytical Performance Criteria for the Global Reconnaissance of Antibiotics and Other Pharmaceutical Residues in the Aquatic Environment Using Liquid Chromatography-Tandem Mass Spectrometry

Luisa F. Angeles | Diana S. Aga
  • Special Issue
  • - Volume 2018
  • - Article ID 7965124
  • - Research Article

Determination of Tobramycin in M9 Medium by LC-MS/MS: Signal Enhancement by Trichloroacetic Acid

Liusheng Huang | Janus Anders Juul Haagensen | ... | Katherine Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 1308167
  • - Review Article

MS-Based Analytical Techniques: Advances in Spray-Based Methods and EI-LC-MS Applications

Federica Bianchi | Nicolò Riboni | ... | Maria Careri
  • Special Issue
  • - Volume 2018
  • - Article ID 1292954
  • - Research Article

High-Precision In Situ 87Sr/86Sr Analyses through Microsampling on Solid Samples: Applications to Earth and Life Sciences

Sara Di Salvo | Eleonora Braschi | ... | Lorella Francalanci
  • Special Issue
  • - Volume 2018
  • - Article ID 8341630
  • - Research Article

Analysis of Polycyclic Aromatic Hydrocarbons in Ambient Aerosols by Using One-Dimensional and Comprehensive Two-Dimensional Gas Chromatography Combined with Mass Spectrometric Method: A Comparative Study

Yun Gyong Ahn | So Hyeon Jeon | ... | Ji Yi Lee
  • Special Issue
  • - Volume 2018
  • - Article ID 8274131
  • - Research Article

Development and Validation of an LC-MS/MS Method and Comparison with a GC-MS Method to Measure Phenytoin in Human Brain Dialysate, Blood, and Saliva

Raphael Hösli | Stefan König | Stefan F. Mühlebach
Journal of Analytical Methods in Chemistry
 Journal metrics
Acceptance rate47%
Submission to final decision88 days
Acceptance to publication57 days
CiteScore2.400
Impact Factor1.878
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