Table of Contents
Journal of Anesthesiology
Volume 2015, Article ID 158317, 6 pages
Clinical Study

Postoperative Etoricoxib versus Ketoprofen Administration for Pain Management after Total Knee Arthroplasty: A Randomized, Double-Blind Controlled Study

1Department of Anesthesiology, Foisor Orthopedics Clinical Hospital, Bulevardul Ferdinand No. 35-37, 021382 Bucharest, Romania
2Foisor Orthopedics Clinical Hospital, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Strada Dionisie Lupu No. 37, 020022 Bucharest, Romania

Received 30 August 2015; Revised 4 December 2015; Accepted 14 December 2015

Academic Editor: Thomas Engelhardt

Copyright © 2015 Simona Cionac Florescu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This randomized double-blind study compared the analgesic efficacy and tolerability of etoricoxib versus ketoprofen in 165 patients with elective total primary knee arthroplasty. Methods. After ethical committee approval, 165 patients were randomized in 3 groups: the etoricoxib group (E) receiving etoricoxib 120 mg/day, at the end of surgery and in the first postoperative day; the ketoprofen group (K) receiving ketoprofen 2 pills of 100 mg/day, the first at the end of surgery and then 1 pill every 12 hours in the surgery day and the first postoperative day; the placebo group (P). All groups received postoperatively the same analgesia protocol when NRS is over 3 with IV Perfalgan and morphine. The effectiveness was evaluated by the time from the initiation of spinal anesthesia until the first analgesic dose, the total amount of morphine administered in the surgery day and the first postoperative day, and the frequency of patients with side effects and necessary amount of adjuvant medication. Results. The baseline demographic characteristics were similar among the 3 groups. In both study days etoricoxib provided an analgesic effect superior to placebo and to ketoprofen, the total administered morphine being significantly lower in etoricoxib group. There were no statistically significant differences between groups regarding the side effects.