Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells
Figure 3
Quantitative data showing changes obtained from the DNA cytometry results, at the growth phase, presenescence, and senescence averaged from all experiments and the corresponding proportions of cells displaying nuclear positivity for p21. Significant increase of the 4C fraction accompany transition from presenescence to senescence (). Increase of the proportion of hypertetraploid cells, in parallel to considerable increase of the proportion of p21-positive cells, accompany the whole process.
