| | Enzymatic activity | Localisation | Substrates/targets | Function |
| SIRT1 | Deacetylase | Nuclear/cytoplamic | p53, FOXO, NFκB, MyoD, Ku70, LXR, PPARγ, p300, Tat, PCAF, ERα, AR, SMAD7, PCAF, p73, Sox9, HES1, PGC1α, HEY2, NcoR/SMRT, E2F1, RelA/p65 | Glucose metabolism, fatty-acid and cholesterol metabolism, differentiation, insulin secretion, and neuroprotection | SIRT2 | Deacetylase | Nuclear/cytoplamic | α-tubulin, FOXO | Cell-cycle control, tubulin deacetylation | SIRT3 | Deacetylase | | AceCS2, GDH complex1 | ATP production, regulation of mitochondrial proteins deacetylation, and fatty-acid oxidation | | | Mitochondrial | | | SIRT4 | ADP-ribosylotransferase | | GDH, IDE, ANT | Insulin secretion | SIRT5 | Deacetylase | | CPS1 | Urea cycle | SIRT6 | Deacetylase ADP-ribosylotransferase | Nuclear | NFκB, Hif1α, helicase, DNA polymeraseβ | Telomeres and telomeric functions, DNA repair | SIRT7 | Deacetylase | Nuclear | RNA polymerase type I, E1A, SMAD6 | RNA polymerase I transcription |
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