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Journal of Aging Research
Volume 2012, Article ID 121390, 16 pages
Review Article

Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA

Received 28 March 2011; Revised 10 October 2011; Accepted 28 October 2011

Academic Editor: Paula Bickford

Copyright © 2012 Hao Qian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.