Table 1: Age-associated changes in PGs and TxA2 and their synthases and receptors.


COX1/2 (hum, r, m)Mesenteric microvesselsAdult, agedIncrease[21, 29, 33, 34, 42, 63, 8486]
PGI2 (hum)BloodAdolescent, agedDecrease[112, 116]
PGIS (r)Aorta, coronary artery in heartAdults, agedIncrease[85, 86, 110, 120]
IP (r)AortaAdults, agedDecrease[84, 85, 121]
PGE2 (r)Coronary artery in heartAgedIncrease[120]
cPGES (r),AortaOld adultN/S[84]
mPGES-1 (r)AortaOld adultN/S[84]
mPGES-2 (r)AortaOld adultIncrease[84]
EP1–3 (r)AortaOld adultN/S[84]
EP4 (r)AortaOld adultIncrease[84]
PGF2α (ham, r)AortaAgedIncrease[110, 148]
PGFS (r)AortaOld adultIncrease[84]
FP (r)AortaOld adultN/S[84]
PGDS (r)AortaOld adultIncrease[84]
DP (r)AortaOld adultN/S[84]
TxA2 (r)Aorta or mesenteric arteryIncrease[42, 86, 172]
TXS (r)AortaOld adultIncrease[84]
TP (r)AortaOld adultN/S[84]

hum: human; ham: hamster; r: rat; m: mouse; N/S: not significant.
Definition of age groups: human, adolescent, 13–19 years; adult, 20–60 years; aged, >60 years. Hamster, aged, >18 months. Rat, young adult, 3–6 months; old adult, 6–18 months; aged >24 months.