Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Table 2

Prostaglandin-related pharmacological agents in the treatment of cardiovascular diseases.

Modulator	Drugs (trade name)	Clinical application	References
PGI2 and its stable analogues	Epoprostenol sodium (Flolan), Beraprost sodium (Procyclin), Iloprost (Ventavis), Treprostinil (Remodulin)	Primary pulmonary hypertension, pulmonary arterial hypertension	[200–207]
PGE2 and its analogues	Dinoprostone, Viprostol	Congenital heart disease	[208–210, 214–217]
TXS inhibitors	Dazoxiben, Camonagrel, Picotamide (Dusodril)	Thrombosis, atherosclerosis, arrhythmias	[218–226]
TP inhibitors	Picotamide, S18886 (Triplion)	Thrombosis, atherosclerosis, ischemic stroke, myocardial infarction	[84, 223–227]
COX1 inhibitor	Aspirin	Thrombosis, atherosclerosis, ischemic stroke, myocardial infarction	[231–235]