Association of Social Engagement with Brain Volumes Assessed by Structural MRI
Table 3
Adjusted associations between change in ROI volumes (independent variable) and social engagement (dependent variable).
ROI
ROI standardized coefficient1
value
Total brain volume
0.023
0.713
Total gray matter (GM)
0.062
0.299
Total white matter (WM)
−0.039
0.494
Gray matter lobes
Frontal GM
0.032
0.599
Temporal GM
0.112
0.055
Parietal GM
0.092
0.133
Occipital GM
−0.011
0.849
White matter lobes
Frontal WM
0.010
0.851
Temporal WM
0.034
Parietal WM
−0.035
0.526
Occipital WM
0.046
0.416
Other structures (GM and WM)
Cerebellum
0.022
0.695
Medial structures
0.005
0.937
Cingulate gyrus
−0.023
0.696
Insula
−0.014
0.803
Corpus callosum
−0.019
0.730
Internal capsule
0.067
0.244
Hippocampus
0.005
0.934
Amygdala
0.050
0.368
Entorhinal cortex
0.027
0.633
From models adjusted for age, education, intracranial volume, race/ethnicity, hypertension, diabetes, handedness, and control status.
1Social engagement at time of 2nd MRI was the dependent variable. Bold: .
