Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane

<table>The generation of reactive oxygen species in mitochondria following ischemia-reperfusion. Amobarbital treatment during early reperfusion decreased net H<sub>2</sub>O<sub>2</sub> production in subsarcolemmal mitochondria (SSM) compared to untreated hearts when glutamate was used as a complex I substrate. Amobarbital also tended to decrease net H<sub>2</sub>O<sub>2</sub> production in interfibrillar mitochondria (IFM) compared to untreated hearts (<svg height="11.1875" id="M38" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.1875" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.1875)">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">6</tspan>
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</g>
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</svg>). Data are expressed as mean ± SEM; *<svg height="11.25" id="M39" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</g>
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</svg> versus untreated. <svg height="11.1" id="M40" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 40.625 11.1" width="40.625" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-63.12)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑁</tspan>
<tspan style="font-size: 12.50px; " x="14.103384" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="26.143772" y="0">5</tspan>
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</svg> in each group.</table>

Journal of Aging Research

fig7

Figure 7

Figure 7: Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane 

Figure 7 | Blockade of Electron Transport at the Onset of Reperfusion Decreases Cardiac Injury in Aged Hearts by Protecting the Inner Mitochondrial Membrane 