White Matter Lesion Assessment in Patients with Cognitive Impairment and Healthy Controls: Reliability Comparisons between Visual Rating, a Manual, and an Automatic Volumetrical MRI Method—The Gothenburg MCI Study

Table 3

Inter-rater and inter-method reliability. *Correlation was significant at the 0.05 level (2-tailed). **Correlation was significant at the 0.01 level (2-tailed). ManWML is manual MRIcron volumetry; 𝑛=27. Anterior is the manual MRIcron assessed volume anterior of the quadrigeminal plate. Posterior is the manual MRIcron assessed volume posterior of the quadrigeminal plate. ManWML versus AutoWML is the manual MRIcron volumetry correlation to the automatic FreeSurfer volumetry. Rho below T3 is the Spearman correlation, and ICC below T3 is the intraclass correlation in the lower two tertiles. Rho in T3 is the Spearman correlation and ICC in T3 the intraclass correlation in the highest tertile. The reliability was significantly higher in the highest tertile for all methods.

	Kendall's tau-b	ICC	ICC below T3	ICC in T3	Rho	Rho below T3	Rho in T3
Inter-rater reliability
Fazekas	0.88**	0.87**	0.65**	0.86**	0.89**	0.65**	0.92**
ManWML	0.45*	0.97**	0.19	0.95**	0.60**	−0.03	0.94**
Anterior					0.63**	0.23	0.94**
Posterior					0.82**	0.56*	1.00**
Inter-method reliability
ManWML versus AutoWML	0.48**	0.51**	0.14**	0.44**	0.65**	0.38**	0.74**