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Journal of Aging Research
Volume 2015, Article ID 934162, 6 pages
http://dx.doi.org/10.1155/2015/934162
Clinical Study

An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder

1Department of Mental Health and Behavioral Sciences, VA Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA
2Department of Psychiatry, Creighton University School of Medicine, 3528 Dodge Street, Omaha, NE 68131, USA
3Baptist Health System, 3201 4th Avenue South, Birmingham, AL 35222, USA
4Mental Health Service, Orlando VA Medical Service, 5201 Raymond Street, Orlando, FL 32803, USA
5Department of Psychiatry, University of Central Florida College of Medicine, 6850 Lake Nona Boulevard, Orlando, FL 32827, USA

Received 2 October 2014; Revised 16 March 2015; Accepted 5 April 2015

Academic Editor: Elke Bromberg

Copyright © 2015 Sriram Ramaswamy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. Kessler, P. Berglund, O. Demler, R. Jin, K. R. Merikangas, and E. E. Walters, “Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication,” Archives of General Psychiatry, vol. 62, no. 6, pp. 593–602, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. D. D. Blake, T. M. Keane, P. R. Wine, C. Mora, K. L. Taylor, and J. A. Lyons, “Prevalence of PTSD symptoms in combat veterans seeking medical treatment,” Journal of Traumatic Stress, vol. 3, no. 1, pp. 15–27, 1990. View at Publisher · View at Google Scholar · View at Scopus
  3. C. W. Hoge, C. A. Castro, S. C. Messer, D. McGurk, D. I. Cotting, and R. L. Koffman, “Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care,” The New England Journal of Medicine, vol. 351, no. 1, pp. 13–22, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. B. M. Elzinga and J. D. Bremner, “Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)?” Journal of Affective Disorders, vol. 70, no. 1, pp. 1–17, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. M. D. Horner and M. B. Hamner, “Neurocognitive functioning in posttraumatic stress disorder,” Neuropsychology Review, vol. 12, no. 1, pp. 15–30, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Brandes, G. Ben-Schachar, A. Gilboa, O. Bonne, S. Freedman, and A. Y. Shalev, “PTSD symptoms and cognitive performance in recent trauma survivors,” Psychiatry Research, vol. 110, no. 3, pp. 231–238, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Gil, A. Calev, D. Greenberg, S. Kugelmass, and B. Lerer, “Cognitive functioning in post-traumatic stress disorder,” Journal of Traumatic Stress, vol. 3, no. 1, pp. 29–45, 1990. View at Publisher · View at Google Scholar · View at Scopus
  8. M. W. Gilbertson, T. V. Gurvits, N. B. Lasko, S. P. Orr, and R. K. Pitman, “Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder,” Journal of Traumatic Stress, vol. 14, no. 2, pp. 413–432, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. J. J. Vasterling, J. I. Constans, K. Brailey, and P. B. Sutker, “Attention and memory dysfunction in posttraumatic stress disorder,” Neuropsychology, vol. 12, no. 1, pp. 125–133, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. J. J. Vasterling, L. M. Duke, K. Brailey, J. I. Constans, A. N. Allain Jr., and P. B. Sutker, “Attention, learning, and memory performances and intellectual resources in Vietnam veterans: PTSD and no disorder comparisons,” Neuropsychology, vol. 16, no. 1, pp. 5–14, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Jelinek, D. Jacobsen, M. Kellner et al., “Verbal and nonverbal memory functioning in posttraumatic stress disorder (PTSD),” Journal of Clinical and Experimental Neuropsychology, vol. 28, no. 6, pp. 940–948, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. G. E. Johnsen, P. Kanagaratnam, and A. E. Asbjørnsen, “Memory impairments in posttraumatic stress disorder are related to depression,” Journal of Anxiety Disorders, vol. 22, no. 3, pp. 464–474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. R. S. MacKin, J. A. Lesselyong, and K. Yaffe, “Pattern of cognitive impairment in older veterans with posttraumatic stress disorder evaluated at a memory disorders clinic,” International Journal of Geriatric Psychiatry, vol. 27, no. 6, pp. 637–642, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. J. J. Vasterling, S. P. Proctor, P. Amoroso, R. Kane, T. Heeren, and R. F. White, “Neuropsychological outcomes of army personnel following deployment to the Iraq War,” Journal of the American Medical Association, vol. 296, no. 5, pp. 519–529, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. P. B. Sutker, J. J. Vasterling, K. Brailey, and A. N. Allain Jr., “Memory, attention, and executive deficits in POW survivors: contributing biological and psychological factors,” Neuropsychology, vol. 9, no. 1, pp. 118–125, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Yehuda, “Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder,” in Psychobiology of Posttraumatic Stress Disorder (Annals of the New York Academy of Sciences), A. C. McFarlane and R. Yehuda, Eds., vol. 821, pp. 57–75, Academy of Sciences, New York, NY, USA, 1997. View at Google Scholar
  17. T. V. Gurvits, M. E. Shenton, H. Hokama et al., “Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder,” Biological Psychiatry, vol. 40, no. 11, pp. 1091–1099, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Kitayama, V. Vaccarino, M. Kutner, P. Weiss, and J. D. Bremner, “Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis,” Journal of Affective Disorders, vol. 88, no. 1, pp. 79–86, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. D. R. Ziegler, W. E. Cullinan, and J. P. Herman, “Organization and regulation of paraventricular nucleus glutamate signaling systems: N-methyl-D-aspartate receptors,” The Journal of Comparative Neurology, vol. 484, no. 1, pp. 43–56, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Nair and S. S. Ajit, “The role of the glutamatergic system in posttraumatic stress disorder,” CNS Spectrums, vol. 13, no. 7, pp. 585–591, 2008. View at Google Scholar · View at Scopus
  21. M. A. Hertzberg, M. I. Butterfield, M. E. Feldman et al., “A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder,” Biological Psychiatry, vol. 45, no. 9, pp. 1226–1229, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Kavirajan, “Memantine: a comprehensive review of safety and efficacy,” Expert Opinion on Drug Safety, vol. 8, no. 1, pp. 89–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Sani, G. Serra, G. D. Kotzalidis et al., “The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence,” CNS Drugs, vol. 26, no. 8, pp. 663–690, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Zdanys and R. R. Tampi, “A systematic review of off-label uses of memantine for psychiatric disorders,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 6, pp. 1362–1374, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Minkeviciene, P. Banerjee, and H. Tanila, “Cognition-enhancing and anxiolytic effects of memantine,” Neuropharmacology, vol. 54, no. 7, pp. 1079–1085, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. A. Battista, R. Hierholzer, H. R. Khouzam, A. Barlow, and S. O'Toole, “Pilot trial of memantine in the treatment of posttraumatic stress disorder,” Psychiatry, vol. 70, no. 2, pp. 167–174, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. M. P. Chopra, K. M. Trevino, and N. W. Kowall, “Memantine for posttraumatic stress disorder in an older veteran,” Journal of Clinical Psychopharmacology, vol. 31, no. 6, pp. 787–788, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Randolph, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Harcourt, The Psychological Corporation, San Antonio, Tex, USA, 1998.
  29. E. R. Peskind, S. G. Potkin, N. Pomara et al., “Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial,” American Journal of Geriatric Psychiatry, vol. 14, no. 8, pp. 704–715, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. W. W. Beatty, J. W. Mold, and S. T. Gontkovsky, “RBANS performance: influences of sex and education,” Journal of Clinical and Experimental Neuropsychology, vol. 25, no. 8, pp. 1065–1069, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Felmingham, L. M. Williams, T. J. Whitford et al., “Duration of posttraumatic stress disorder predicts hippocampal grey matter loss,” NeuroReport, vol. 20, no. 16, pp. 1402–1406, 2009. View at Publisher · View at Google Scholar · View at Scopus