The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents

Figure 1

The effects of ovariectomy (ovx) and 17β-estradiol (ovx + E₂) on 24-hour voluntary running distance in rats from the cohorts of initial ages of five months (A) and ten months (B). Values are means ± SEM. Bars that do not share the same superscript letters are significantly () different from each other ( per treatment group). Voluntary running activity measured by activity wheel and distance counter in individual cages for 24 hours between one and two weeks before sacrifice was significantly decreased in older ovx rats (younger ovx rats tended to have a lower activity). E₂ administration prevented the lower activity level.