The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents

Figure 2

3D trabecular images representative of proximal right tibia of sham (a), ovariectomy (ovx) (b), and 17β-estradiol (ovx + E₂) (c). The images were acquired using μCT (Methods). Ovariectomy decreased trabecular bone structure when compared to sham in rats from the cohort of initial age of ten months. This effect was prevented by E₂ administration. Similar effects were observed in younger animals ( per treatment group).

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