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Journal of Aging Research
Volume 2017, Article ID 9851380, 11 pages
https://doi.org/10.1155/2017/9851380
Research Article

Knockout of Vasohibin-1 Gene in Mice Results in Healthy Longevity with Reduced Expression of Insulin Receptor, Insulin Receptor Substrate 1, and Insulin Receptor Substrate 2 in Their White Adipose Tissue

1Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
2Department of Diabetes and Metabolism, Graduate School of Medicine, Tokyo University, Tokyo, Japan

Correspondence should be addressed to Yasufumi Sato; pj.ca.ukohot@3b.otas.imufusay

Received 13 December 2016; Revised 30 January 2017; Accepted 16 February 2017; Published 6 March 2017

Academic Editor: Barbara Shukitt-Hale

Copyright © 2017 Eichi Takeda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Gross appearance of pancreatic islets in Supporting Figure 1; the basal expression profile of VASH1 in various human organs in Supporting Figure 2; down-regulation of vash1 expression and normalization of insr, irs-1, and irs-2 expressions in WAT with aging in Supporting Figure 3; GTT and ITT prior to HFD in Supporting Figure 4; plasma adiponectin and leptin levels in Supporting Figure 5.

  1. Supplementary Material