Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q₁₀

Figure 3

Effect of CoQ10 on respiratory parameters in epithelial tissue. 16 hours prior to measurement, purified biopsies were stored overnight at 4°C in Dispase II. During incubation with Dispase II, the samples were treated with or without 100 µM CoQ10 or CoQ10 carrier control. On the next day, the respiration profile of the separated dermis was analyzed with an XF analyzer. White circles represent untreated samples. CoQ10-treated samples are shown in dark gray circles. Connected circles represent the same donor. ((a) n = 23, linear regression with 95% confidence interval, R² = 0.4354/, deviation from zero = significant; (b) n = 8, mean ± SEM, one-way ANOVA with Dunnett’s multiple comparison test versus control and CoQ10 carrier control, ). Control cells correspond to 1.0. OCR = oxygen consumption rate.

(a)

(b)